ClariFix® cryotherapy device

Over 87 million Americans suffer from chronic rhinitis.1-2 Historically, patients with chronic rhinitis (having symptoms such as frequent runny nose, congestion and or post-nasal drip) have had limited surgical treatment options such as a vidian neurectomy.3

Stryker's ClariFix device goes straight to the root of chronic rhinitis - the overactive nerves. Using a minimally invasive treatment called cryotherapy, the ClariFix device applies focal, controlled freezing to target tissue under direct visualization.4

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Features and benefits

ClariFix cryotherapy has been shown to be safe and effective1

  • Backed by 5 clinical studies1, 5-8
  • Minimally invasive
  • Side effects may be mild, fleeting, and resolve on their own1, 5-6
  • More than 50,000 patients treated since 20179
  • Minimal downtime and recovery10
  • Can be performed under local anesthesia
Blowing nose

ClariFix® works to relieve chronic rhinitis symptoms

Studies have shown ClariFix is a simple, clinically proven device that delivers cryotherapy treatment to treat chronic rhinitis.1, 5-8 It allows you to apply focal, controlled freezing to target tissue under direct visualization.4

ClariFix is the only cryotherapy treatment that ablates the posterior nasal nerves and is supported with two years of clinical data.1

How cryotherapy works

ClariFix cryotherapy works by creating second degree nerve damage at the posterior nasal nerves.11-12 This nerve damage results in the loss of axon continuity distal to the freeze, but preservation of the perineurium, endoneurium, and epineurium.10 Cyrosurgery has demonstrated rapid regeneration of mucosal structures and function. Additionally, large blood vessels have shown to be resistant to the freezing and their function is not impaired.15

Before ClariFix

Treatment target is posterior aspect of middle meatus at point of attachment to lateral wall.

During ClariFix

ClariFix device is inserted into nasal cavity under visualization with tip pointed toward lateral wall.

After ClariFix

Basal lamella stops cryoprobe from advancing further.

*Most patients begin to see improvement 30 days post treatment.

Product specifications

Product Ordering no. Description
ClariFix system CFX-2000 1 system

One system includes: 1 ClariFix cryotherapy device, 2 cryogen canisters and 2 sterile canister caps


87 million
Americans suffer from chronic rhinitis1-2
of chronic rhinitis sufferers have symptoms persist after medical management and intervention13
4 out of 5
ClariFix patients reported long-lasting symptom improvement1
of individuals who responded to ipratropium spray also responded to cryotherapy14


Questions about ClariFix

Please be aware of contraindications including cryoglobulinemia, paroxysmal cold hemoglobinuria, cold urticaria, Raynaud’s disease, open and/or infected wounds or other skin conditions at or near the target tissue. Treat patients with caution who have diabetes, sensitivity to cold, neuropathic disorders, bleeding disorders or impaired peripheral circulation in the area to be treated.4

Most patients see improvement by 30 days post treatment.

In a clinical study, patients reported a significant decrease in runny nose and nasal congestion with four out of five patients reporting long-lasting symptom relief.1, 7-8

Typically, the ClariFix application time is 30-45 seconds per side of the nose.4

Typically, an anesthetic is used to numb the inside of the nose, to ensure patient comfort during the procedure. The ClariFix device is placed in the back of the nose and the cryotherapy is applied. Patients may experience slight pressure, a cooling sensation in the nose and/or around the molars, or some discomfort during and/or after the treatment.

Most patients return to their normal activity that same day. In general, there is minimal downtime and recovery.10

The most common side effects associated with the ClariFix cryotherapy procedure are temporarily increased congestion, transient pain or discomfort, and a headache. Nosebleed is rare, but a potential side effect, and may be increased if the patient has a clotting disorder, uncontrolled high blood pressure, or uses anticoagulants or blood thinners.4

You should discuss with your patient any recommendations to continue taking prescribed rhinitis medications after the procedure.

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