Information for healthcare professionals

Adherus

AutoSpray Dural Sealant

Strong under pressure

Close effectively with Adherus AutoSpray Dural Sealant, Stryker’s adjunct to standard methods of dural repair.

Adherus helps provide watertight closure and reduce chances of CSF leaks during cranial and spinal procedures. Even more importantly, it's designed to provide dural closure during the critical phase of dural healing.

Request product

Long lasting

Adherus maintains significant burst strength above physiological intracranial pressure in an in vitro model. With an average of 17 cross linking end groups, Adherus has an increased strength.^1,2

Adheres to the dura during the entire healing period of 13 - 15 days⁶
Completely resorbs after 90-125 days³

Low swelling

Hydrogels, by nature, absorb liquid when placed in a solution, which can lead to swelling of the implant. Adherus displayed a dimensional change of only 8% due to water uptake compared to other dural sealants (38%).²

Easy set-up and application

Adherus hydrogel is ready to use in 1- minute; it sets in approximately one second and remains where it is applied.³

Additionally, the applicator consists of an integrated air pump, which assists on the application of the hydrogel by:

Creating an "aerosol" effect on the target spot
Preventing blockages at the tip

Designed for better patient outcomes

infection

There were no device related infections and no cases of meningitis among subjects treated with Adherus AutoSpray Dural Sealant in a pivotal randomized controlled trial.⁴

impermeability

98.4% of patients treated with Adherus did not require a second application of the product intraoperatively to achieve tight closure.⁴

leak prevention

Adherus was found to have a 99.1% success rate^4a at preventing CSF leaks in a 17-center randomized controlled trial.⁴

Your options

Both Adherus AutoSpray and AutoSpray Extended Tip applicators allow the dural sealant hydrogel to be applied without any adaptors. Choose the most convenient option.

adherus-dural-sealant-highlight-graphic-v3

Adherus AutoSpray Dural Sealant

adherus-extended-tip-product-spotlight-image

Adherus Extended Tip AutoSpray Dural Sealant

"Adherus is effective; it reduces CSF leak rates. The application of the product is easy, straightforward and consistent."

Dr. Michael McDermott
M.D., Neurosurgeon

Get brochure

Do you have a question? Fill out the form and our team will get back to you shortly.

Thank you!

*Your request will be honored in accordance with local law requirements and MedTech code.

References:

1. van Doormaal T, Kinaci A, van Thoor S, Redegeld S, Bergmann W, van der Zwan A. Usefulness of Sealants for Dural Closure: Evaluation in an In Vitro Model. Oper Neurosurg. 2018;15(4):425-432. doi:10.1093/ons/opx260
2. Strong MJ, Carnahan MA, D'Alessio K, Butlin JDG, Butt MT, Asher AL. Preclinical characterization and safety of a novel hydrogel for augmenting dural repair. Mater Res Express. 2015;2(9):95401. doi:10.1088/2053-1591/2/9/095401
3. Adherus AutoSpray and Adherus AutoSpray ET Dural Sealant, Instructions for use.
4. Tew JM, Strong MJ, West AG, et al. A pivotal randomized clinical trial evaluating the safety and effectiveness of a novel hydrogel dural sealant as an adjunt to dural repair. Open Neurosurg. 2017;13(2):204-212. doi:10.1093/ons/opw004
a. The 99.1% success rate are results of the 14-day findings. The value dropped to 96.6% after 45 days.
5. Kinaci A, Algra A, Heuts S, O'Donnell D, van der Zwan A, van Doormaal T. Effectiveness of Dural Sealants in Prevention of Cerebrospinal Fluid Leakage After Cranitomoy: A Systemic Review. World Neurosurg. 2018;118:368-376.el. doi:10.1016/j.wneu.2018.06.196
6. Zhou F, Chen G, Zhang JM, Huang ZS. An in vitro culturing model for rabbit dural cells. Ann Clin Lab Sci. 2006 Summer;36(3):341-4.

CRAN-ADH OTHW-776700