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Bone Cement

Simplex P with Tobramycin: The Antibiotic of Choice

Tobramycin is the antibiotic-of-choice for more than 75% of orthopaedic surgeons in the US1  for several important reasons:

  • Ability to withstand exothermic temperatures of polymerizing cement
  • Commercially pre-blended, allowing even distribution throughout the mixture

 

Simplex™ P with Tobramycin Bone Cement is indicated for the fixation of prostheses to living bone in the second stage of a two-stage revision for total joint arthroplasty.

Stryker Corporation or its divisions or other corporate affiliated entities own, use or have applied for the following trademark(s) or service mark(s): Simplex P Cement with Tobramycin. All other trademarks are trademarks of their respective owners or holders.
References

1. Fish DN, Hoffman HM, Danziger LH. Antibiotic-impregnated cement use in US hospitals. AM J Hosp Pharm. 1992; 49:2469-2474.

2. Harris W, McCarthy J, O'Neil D. Femoral component loosening using contemporary techniques of femoral cement fixation. J Bone Joint Surg. 1982; 64A (7): 1063-1067.]

3. Nijhof M, Dhert W, Tillman P, Verbout A, Fleer A. Release of tobramycin-containing bone cement in bone and serum of rabbits. J Mat Sci Ma Med. 1997; 8(12):342-353.

4. Sterling GJ, Potter JM, Koerbin G, Crawford S, Crawford R, 2002. The pharmacokinetics of Simplex P Tobramycin Bone Cement. A study investigating the elution characteristics of Simplex P Tobramycin Bone Cement in total hip replacement. J Bone Joint Surg (Br) 2003; 85-B:646-9.

5. Physicians Desk Reference Edition 54, Medical Economics Company, Inc., Montvale NJ. 2000; 1628-1631.

6. Barrack R, Mulroy R, Harris W. Improved cementing techniques and femoral component loosening in young patients with hip arthroplasty: A 12 year radiographic review. J Bone Joint Surg (Br). 1992; 74B: 385-389.

7. Mulroy W, Estok D, Harris W. Total hip arthroplasty with use of so-called second generation cementing techniques. J Bone Joint Surg. 1995; 77A (12): 1845-1852.

8. Linden U. Fatigue properties of bone cement: Comparison of mixing

9. Popham GJ, Mangino P, Seligson D, Henry SL. Antibiotic-impregnated beads. Part II: Factors in antibiotic selection. Orthop Rev. 1991 Apr; 20(4):331-7