Reference Materials
General Review Articles
Reddi, A.H. Bone Morphogenetic Proteins: From Basic Science to Clinical Applications. JBJS 83-A(Supp 1, Part 1):1-6, 2001
Seeherman, H. The Influence of Delivery Vehicles and Their Properties on the Repair of Segmental Defects and Fractures with osteogenic Factors. JBJS 830A(Supp 1, Part 2):79-81, 2001
Ray, R.P., Wharton, K.A. Minireview: Twisted Perspective: New Insights into Extracellular Modulation of BMP Signaling during Development. Cell 104:801-804, 2001
Lo, I.K.Y., Randle, J.A., Majima, T., Thornton, G., Rattner, J.B., Shrive, N.G., Frank, C.B., Hart, D.A. New directions in understanding and optimizing ligament and tendon healing. Curr Opin Ortho 11:421-428, 2000
Kirker-Head, C.A. Potential applications and delivery strategies for bone morphogenetic proteins Advanced Drug Delivery. Rev 43:65-92, 2000
Khan, S.N., Bostrom, M.P.G., Lane, J.M. Bone Growth Factors. Ortho Clinics North America 31(3):375-387, 2000
Zlotolow, D.A., Vaccaro, A.R., Salamon, M.L., Albert, T.J. The Role of Human Bone Morphogenetic Proteins in Spinal Fusion. J Am Acad Orthop Surg 8:3-9, 2000
Helm, G.A., Alden, T.D., Sheehan, J.P., Kallmes, D. Bone Morphogenetic Proteins and Bone Morphogenetic Protein Gene Therapy in Neurological Surgery: A Review. Neurosurgery 46:1213-1222, 2000
Service R.F. Tissue Engineers Build New Bone. Science 289(548):1421-1640, 2000
Bostrom, M.P.G., Yang, X., Koutras, I. Biologics in bone healing. Curr Opin Ortho 11:403-412, 2000
Yoo, J.U., Johnstone, B. Mesenchymal stem cells and musculoskeletal repair. Curr Opin Ortho 11:391-396, 2000
Goomer, R.S., Amiel, D. Repair of articular cartilage defects by ex-vivo gene therapy. Curr Opin Ortho 11:378-382, 2000
Miclau, T., Helms, J.A. Molecular aspects of fracture healing. Curr Opin Ortho 11:367-371, 2000
Massague, J., Blain, S.W., Roger, S.L TGF-ß Signaling in Growth Control, Cancer, and Heritable Disorders. Cell, 103:295-309, 2000
Miyazono, K. TGF-ß signaling by Smad proteins. Cytokine Growth Fac Rev 11:15-22, 2000
Reddi, A.H. Bone morphogenetic proteins and skeletal development: the kidney-bone connection. Pediatr Nephrol 14:598-601, 2000
Lewandrowski, K-U., Ozuna, R.M., Pedlow, F.X., Hecht, A.C. Advances in the biology of spinal fusion: growth factors and gene therapy. Curr Opin Ortho 11(3):167-175, 2000
Cook, S .Preliminary Report: New Technology- Preclinical and Clinical Evaluation of Osteogenic Protein-1 (BMP-7) in Bony Sites. Orthopedics 22(7):669-671, 1999
Smith W.C. TGF-ß inhibitors: new and unexpected requirements in vertebrate development. TIG 15(1):3-5, 1999
Piek, E., Heldin, C.H., Ten Dijke, P. Specificity, diversity and regulation in TGF-ß superfamily signaling. FASEB 13:2105-2124, 1999
Demers, C., Hamdy, R. C. Bone Morphogenetic Proteins. Science Medicine 6(6):8-17, 1999
Liu, Z., Dequeker, J., Lammens, J., Luyten, F.P. Molecular signaling in bone fracture healing and distraction osteogenesis. Histology Histopathology 14(2):587-595, 1999
Ring, C.J., Cho, K.W. Specificity in transforming growth factor-beta signaling pathways. Am J Hum Genet 64(3):691-697, 1999
Schmitt, J. M., Hwang, K., Winn, S. R., Hollinger, J. O. Bone morphogenetic proteins: and update on basic biology and clinical relevance. J Ortho Res 17(2):269-278, 1999
Richardson, M.K., Allen, S.P., Wright, G.M., Raynaud, A., Hanken, J. Somite number and vertebrate evolution. Development 125:151-160, 1998
Merino, R., Ganan, Y., Macias, D., Economides, A.N., Sampath, K.T., Hurle, J.M. Morphogenesis of digits in the Avian Limb Is Controlled by FGFs, TGFßs, and Noggin through BMP Signaling. Dev Biol 2000:35-45, 1998
Massague, J. TGF-ß Signal Transduction. Annu Rev Biochem 67:753-791, 1998
Solhein, E. Growth factors in bone. Int Ortho 22(6):410-416, 1998
Brekke, J.H., Toth, J.M. Principles of tissue engineering applied to programmable osteogenesis. J Biomed Mater Res 43(4):380-98, 1998
Sandhu, H.S., Boden, S.D. Biologic enhancement of spinal fusion. Ortho Clinics North America 29(4):621-631, 1998
Reddi, A. H. Initiation of fracture repair by bone morphogenetic proteins. Clin Ortho suppl 355:S66-72, 1998
Mont, M. A., Jones, L. C., Einhorn, T. A., Hungerford, D. S., Reddi, A. H. Osteonecrosis of the femoral head. Potential treatment with growth and differentiation factors. Clin Ortho Suppl 355:S314-315, 1998
Niyibizi, C., Baltzer, A., Lattermann, C., Oyama, M., Whalen, J. D., Robbins, P. D., Evans, C. H. Potential role for gene therapy in the enhancement of fracture healing. Clin Ortho suppl 355:S148-153, 1998
Ferguson, C. M., Miclau, T., Hu, D., Alpern, E., Helms, J. A. Common molecular pathways in skeletal morphogenesis and repair. Ann N Y Acad Sci 857:33-42, 1998
Bostrom, M. Expression of bone morphogenetic proteins in fracture healing. Clin Ortho Related Res 355:116-123, 1998
Bostrom, M., Camacho, N. Potential role of bone morphogenetic proteins in fracture healing. Clin Ortho Related Res 355:274-282, 1998
Cho, K.W., Blitz, I.L. BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation. Curr Opin Genet Dev 8(4):443-449, 1998
Kawabata, M., Imamura, T., Miyazono, K. Signal transduction by bone morphogenetic proteins. Cytokine Growth Fac Rev 9(1):49-61, 1998
Sakou, T. Bone morphogenetic proteins: From basic Studies to clinical approaches. Bone (United States) 22(6):591-603, 1998
Reddi, A.H. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nature Biotech 16:247-252, 1998
Wozney, J.M., Rosen, V. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin Ortho Rel Res (346):26-37, 1998
Woozney, J.M. The bone morphogenetic protein family: Multifunctional cellular regulators in the embryo and adult. Eur J Oral Sci 106(1):160-166, 1998
Ripamonti, U., Duneas, N. Tissue morphogenesis and regeneration by bone morphogenetic proteins. Plas Recon Surg 101(1):227-239, 1998
Arora, K., O'Connor, M.B., Warrior, R. BMP Signaling in Drosophila Embryogenesis. Annals New York Academy of Sciences 80-97, 1997
Roelen, B.A.J., Goumans, M.J., van Rooijen, M.A., Mummery, C.L. Differential expression of BMP receptors in early mouse development. Intnl J Dev Biol 41(4):541-549, 1997
Rosen, V., Cox, K., Hattersley, G. Bone morphogenetic proteins. Prin Bone Biol Chap 47:661-671, 1996
Yamashita, H., ten Dijke, P., Heldin, C.H., Miyazono, K. Bone morphogenetic protein receptors. Bone 19(6):569-574, 1996
Rosen, V., Thies, R.S., Lyons, K. Signaling pathways in skeletal formation: A role for BMP receptors. Ann NY Acad Sci 785:59-69, 1996
Karsenty, G., Luo, G., Hofmann, C., Bradley, A. BMP-7 is required for nephrogenesis, eye development, and skeletal patterning. Ann NY Acad Sci 785:98-107, 1996
King, J.A., Storm, E.E., Marker, P.C., Dileone, R.J., Kingsley, D.M. The role of BMPs and GDFs in development of region-specific skeletal structures. Ann NY Acad Sci 785:70-79, 1996
Linkhard, T.A., Subburaman, M., Baylink, D.J. Growth factors for bone growth and repair: IGF, TGF-B and BMP1. Bone 19(1/Supp):1S-12S, 1996
Hogan, B.L.M. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development. Genes Dev 10:1580-1594, 1996
Massague, J. TGF-B signaling: Receptors, transducers, and mad proteins. Cell 85:947-950, 1996
Cook, S.D., Rueger, D.C. Osteogenic protein-1: Biology and applications. Clin Ortho (324):29-38, 1996
Rudkin, G.H., Miller, T.A. Growth-factors in surgery. Plas Recon Surg 97(2):469-476, 1996
Ripamonti, U., Reddi, A.H. Bone morphogenetic proteins: Applications in plastic and reconstructive surgery. Advances in Plas Recon Surg 11:47-73, 1995
Vukicevic, S., Stavljenic, A., Pecina, M. Discovery and clinical applications of bone morphogenetic proteins. Euro J Clin Chem Clin Biochem 33(10):661-671, 1995
Kirkerhead, C.A. Recombinant bone morphogenetic proteins - novel substances for enhancing bone healing. Vet Surg 24(5):408-419, 1995
Ripamonti ,U., Vukicevic, S. Bone morphogenetic proteins - from developmental biology to molecular therapeutics. South African J Sci 91(6):277-280, 1995
Einhorn, T.A. Current concepts review enhancement of fracture-healing. J Bone Joint Surg 77-A(6):940-956, 1995
Wozney, J.M. The potential role of bone morphogenetic proteins in periodontal reconstruction. J Perio 66(6):506-510, 1995
Einhorn, T.A. Enhancement of fracture-healing. J Bone Joint Surg 77-A(6):940-956, 1995
Reddi, A.H. Bone morphogenetic proteins, bone marrow stromal cells, and mesenchymal stem cells. Clin Ortho Rel Res (313):115-119, 1995
Ripamonti, U., Reddi, A.H. Periodontal regeneration - Potential role of bone morphogenetic. J Perio Res 29(4):225-235, 1994
Sampath, T.K., Rueger, D.C. Structure, Function, and Orthopedic Applications of Osteogenic Protein-1 (OP-1). Complications in Ortho 101-107, 1994
Alper, J. Biomedicine - Boning up - Newly isolated proteins heal bad breaks. Sci 263(5145):324-325, 1994
Wolfe, M.W., Cook, S.D. Use of osteoinductive implants in the treatment of bone defects. Med Prog Technol (United States) 20(3-4):155-168, 1994
Kingsley, D.M. What do BMPs do in mammals - Clues from the mouse short ear mutation. Trends in Gen 10(1):16-21, 1994
Reddi, A.H., Cunningham, N.S. Initiation and promotion of bone differentiation by bone morphogenetic proteins. J Bone Miner Res (United States) 8(S2):S499-S502, 1993
Baylink, D.J., Finkelman, R.D., Mohan S. Growth-factors to stimulate bone-formation. J Bone Miner Res 8(S2):S565-S572, 1993
Kenley, R.A., Yim, K., Abrams, J., Ron, E., Turek, T., Marden, L.J., Hollinger, J.O. Biotechnology and bone-graft substitutes. Pharm Res 10(10):1393-1401, 1993
Wang, E.A. Bone morphogenetic proteins (BMPs) - Therapeutic potential in healing bony defects. Trends in Biotech 11(9):379-383, 1993
Elima, K. Osteoinductive proteins. Annals Med 25(4):395-402, 1993
Wozney, J.M. The bone morphogenetic protein family and osteogenesis. Mol Reprod Dev 32(2):160-167, 1992
Lyons, K.M., Jones, C.M., Hogan, B.L. The DVR gene family in embryonic development. Trends Genet (England) 7(11-12):408-412, 1991
Schaub, R.G., Wozney, J. Novel agents that promote bone regeneration. Current Opin Biotech 2:868-871, 1991
Wozney, J.M., Rosen, V., Byrne, M., Celeste, A.J., Moutsatsos, I., Wang, E.A. Growth factors influencing bone development. J Cell Sci Suppl (England) 13:149-156, 1990
Wozney, J.M. Bone morphogenetic proteins. Prog Growth Fac Res (England) 1(4):267-280, 1989