Reference Materials
Molecular Biology / Biochemistry
Mintzer, K.A., Lee, M.A., Runke, G., Trout, J., Whitman, M., Mullins, M.C. Lost-a-fin encodes a type 1 BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation. Development 128:859-869, 2001
Kin, R.Y., Robertson, E.J., Solloway, M.J. Bmp6 and Bmp7 Are Required for Cushion Formation and Septation in the Developing Mouse Heart. Developmental Biology 235:449-466, 2001
Dorai, H., shepard, A., Ozkaynak, E., Lin, K., Jones, S., Oppermann, H., Sampath, K. The 5' Flanking Region of the Human Bone Morphogenetic Protein-7 Gene. Biochem Biophys Res Comm 282:823-831, 2001
Schmid, B., Furthauer, M., Connors, S.A., Trout, J., Thisse, B., Thisse, C. Mullins, M.C. Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. Development 127:957-967, 2000
Yue, J., Frey, R. S., K. M. M. Cross-talk between the Smad 1 and Ras-MEK signaling pathways for TGF-beta. Oncogene 18(11):2033-2037, 1999
Ripamonti, U., Crooks, J., Kirkbride, A.N. Sintered porous hydroxyapatites with intrinsic Osteoinductive activity: geometric induction of bone formation. South African J Science 95:335-343, 1999
Fujii, M., Takeda, K., Imamura, T., Aoki, H., Kuber Sampath, T., Enomoto, S., Kawabata, M., Kato, M. Ichijo, H., Miyazono, K. Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation. Molecular Bio Cell 10:3801-3813, 1999
Nifuji, A., Noda, M., Coordinated Expression of Noggin and Bone Morphogenetic Proteins (BMPs) During Early Skeletogenesis and Induction of Noggin Expression by BMP-7. J Bone Min Res 14(12):2057-2066, 1999
Merino, R., Rodgriquez-Leon, J., Macias, D., Ganan, Y., Economides, A.N., Hurle, J.M. The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb. Development 126:5515-5522, 1999
Chen, MY, Carpenter, D., Zhao, G.Q. Expression of bone morphogenetic protein 7 in murine epididymis is developmentally regulated. Bio Reprod 60(6):1503-1508, 1999
Ponce, M.R., Micol, J.L., Peterson, K.J., Davidson, E.H. Molecular characterization and phylogenetic analysis of SpBMP5-7, a new member of the TGF-beta superfamily expressed in sea urchin embryos. Mol Biol Evol 16(5):634-645, 1999
Pathi, S., Rutenberg, J. B., Johnoson, R. L., Vorkamp, A. Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation. Dev Biol 209(2):239-253, 1999
Sollowary, M. J., Robertson, E.J. Early embryonic lethality in Bmp5; Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development 126(8):1753-1768, 1999
Yamamoto, T. Immunohistochemical localization of bone morphogenetic proteins and their receptors in rat and Human Articular Cartilage. Medical J of Kagoshima University 50(4):123-131, 1999
Dale, K., Sattar, N., Heemskerk, J., Clarke, J.D., Placzek, M., Dodd, J. Differential patterning of ventral midline cells by axial mesoderm is regulated by BMP7 and chordin. Development 126(2):397-408, 1999
Iemura, S.I., Yamamoto, T.S., Takagi, C., Uchiyama, H., Natsume, T., Shimasaki, S., Sugino, H., Ueno, N. Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo. J Proc Natl Acad Sci (United States) 95(16):9337-9342, 1998
Cheifetz, S. RNAse protection assay for BMP type I receptors. Eur J Oral Sci 106(suppl 1):174-178, 1998
Katagiri, T., Boorla, S., Frendo, J.-L., Hogan, B.L.M., Karsenty, G. Skeletal abnormalities in doubly heterozygous BMP4 and BMP7 mice. J Dev Genet (New York) 22(4):340-348, 1998
Tamaki, K., Souchelnytskyi, S., Itoh, S., Nakao, A., Sampath, K., Heldin, C.-H., ten Dijke, P. Intracellular signaling of osteogenic protein-1 through Smad5 activation. J Cell Phys (United States) 177(2):355-363, 1998
Volk, S.W., Luvalle, P., Leask, T., Leboy, P.S. A BMP responsive transcriptional region in the chicken type X collagen gene. J Bone Min Res 13(10):1521-1529, 1998
Macias-Silva, M., Hoodless, P.A., Tang, S.J., Buchwald, M., Wrana, J.L. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J Biol Chem (United States) 273(40):25628-25636, 1998
Afrakhte, M., Moren, A., Jossan, S., Itoh, S., Sampath, K, Westermark, B., Heldin, C.H., Heldin, N.E., ten Dijke, P. Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members. Bioch Bioph Res Comm (United States) 249(2):505-511, 1998
Yazaki, Y., Matsunaga, S., Omishi, T., Nagamine, T., Orguchi, N., Yamamoto, T., Ishidou, Y., Imamura, T., Sakou, T. Immunohistochemical localization of bone morphogenetic proteins and the receptors in epiphyseal growth plate. Anticancer Res (Greece) 18(4A):2339-2344, 1998
Nishimatsu, S., Thomsen, G.H. Ventral mesoderm induction and patterning by bone morphogenetic protein heterodimers, in Canopies embryos. Mech Dev 74(1-2):75-88, 1998
Amthor, H., Christ, B., Weil, M., Patel, K. The importance of timing differentiation during limb muscle development. Current Bio 8(11):642-652, 1998
Onishi, T., Ishidou, Y., Nagamine, T., Yone, K., Imamura, T., Kato, M., Sampath, T.K., ten Dijke, P., Sakou, T. Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats. Bone (United States) 22(6):605-612, 1998
Ericson, J., Norlin, S., Jessell, T.M., Edlund, T. Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Dev (United Kingdom) 125(6):1005-1015, 1998
Takase, M., Imamura, T., Sampath, T.K., Takeda, K., Ichijo, H., Miyazono, K., Kawabata, M. Induction of Smad6 mRNA by bone morphogenetic proteins. Bioch Bioph Res Comm 244(1):26-29, 1998
Nakamura, T., Aikawa, T., Iwamoto-Enomoto, M., Iwamoto, M., Higuchi, Y., Maurizio, P., Kinto, N., Yamaguchi, A., Noji, S., Kurisu, K., Matsuya, T. Induction of osteogenic differentiation by hedgehog proteins. Bioch Bioph Res Comm 237:465-469, 1997
Suzuki, A., Kaneko, E., Maeda, J., Ueno, N. Mesoderm induction by BMP-4 and -7 heterodimers. Bioch Bioph Res Comm 232:153-156, 1997
Wang, S., Krinks, M., Kleinwaks, L., Moos, M. A novel Xenopus homolog of bone morphogenetic protein-7 (BMP-7). Genes Funct 1(4):259-271, 1997
Harada, S.I., Sampath, T.K., Augin, J.E., Rodan, G.A. Osteogenic protein-1 up-regulation of the collagen X promoter activity is mediated by a MEF-2 like sequence and requires an adjacent AP-1 sequence. Mole Endo 11(12):1832-1845, 1997
Piek, E., Franzen, P. Heldin, C-H, ten Dijke, P. Characterization of a 60-kDa cell surface-associated transforming growth factor-beta binding protein that can interfere with transforming growth factor-beta receptor binding. J Cell Phys 173(3):447-459, 1997
Ozkaynak, E., Jin, D., Jelic, M., Vukicevic, S., Oppermann, H. Osteogenic protein-1 mRNA in the uterine endometrium. Bioch Bioph Res Comm 234(1):242-246, 1997
Suzuki, A., Kaneko, E., Ueno, N., Hemmati-Brivanlou, A. Regulation of epidermal induction by BMP2 and BMP7 signaling. Dev Biol (United States) 189:112-122, 1997
Namiki, M., Akiyama, S., Katagiri, T., Suzuki, A., Ueno, N., Yamaji, N., Rosen, V., Wozney, J.M., Suda, T. A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2 induced signal transduction in C2C12 myoblasts. J Biol Chem 272(35):22046-22052, 1997
Hayashi, K., Ishidou, Y., Yonemori, K., Nagamine, T., Origuchi, N., Maeda, S., Imamura, T., Kato, M., Yoshida, H., Sampath, T.K., ten Dijke, P., Sakou, T. Expression and localization of bone morphogenetic proteins (BMPs) and BMP receptors in ossification of the ligamentum flavum. Bone (United States) 21(1):23-30, 1997
Ethier, J.F., Lussier, J.G., Silversides, D.W. Bovine activin receptor type IIB messenger ribonucleic acid displays alternative splicing involving a sequence homologous to Src-homology 3 domain binding sites. Endo 138(6):2425-2434, 1997
Beppu, H., Minowa, O., Miyazono, K., Kawabata, M. cDNA cloning and genomic organization of the mouse BMP type II receptor. Bioch Bioph Res Comm 235(3):499-504, 1997
Koyama, H. Analysis of genes implicated in osteogenic signaling by osteogenic protein-1 (OP-1) using differential display method. Kokubyo Gakkai Zasshi (Japan) 64(2):205-22, 1997
Yonemori, K., Imamura, T., Ishidou, Y., Okano, T., Matsunaga, S., Yoshida, H., Kato, M., Sampath, T.K., Miyazono, K., ten Dijke, P., Sakou, T. Bone Morphogenetic Protein receptors and Activin Receptors are highly expressed in Ossified Ligament Tissues of Patients with Ossification of the Posterior Longitudinal Ligament. Amer J Path 15(4):1335-1347, 1997
Buscher, D., Bosse, B., Heymer, J., Ruther, U. Evidence for genetic control of sonic hedgehog by Gil3 in mouse limb development. Mech Dev (Ireland) 62(2):75-82, 1997
Dudley, A.T., Robertson, E.J. Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP-7 deficient embryos. Dev Dyn 208(3):349-362, 1997
Macias, D., Ganan, Y., Sampath, T.K., Piedra, M.E., Ros, M.A., Hurie, J.M. Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development. Dev 124(6):1109-1117, 1997
Feuerbach, D., Loetscher, E., Buerki, K., Sampath, T.K., Feyen, J.H.M. Establishment and characterization of conditionally immortalized stromal cell lines from a temperature-sensitive T-Ag transgenic mouse. J Bone Min Res 12(2):179-190, 1997
Jena, N., Martin-Seisdedos, C., McCue, P., Croce, C.M. BMP-7 null mutation in mice: developmental defects in skeleton, kidney, and eye. Exp Cell Res (United States) 230(1):28-37, 1997
Karsenty, G., Luo, G., Hofmann, C., Bradley, A. BMP-7 is required for nephrogenesis, eye development, and skeletal patterning. Annals New York Acad Sci 785:98-107, 1996
Hofmann, C., Luo, G.B., Balling, R., Karsenty, G. Analysis of limb patterning in BMP-7-deficient mice. Dev Genetics 19(1):43-50, 1996
Harada, S., Sampath, T.K., Rodan, G.A. Identification of an api-like response region for osteogenic protein-1 in type X collagen promoter. Annals. NY Acad Sci 785:259-260, 1996
Griffith, D.L., Keck, P.C., Sampath, T.K., Rueger, D.C., Carlson, W.D. Three-dimensional structure of recombinant human osteogenic protein-1: structural paradigm for the transforming growth factor beta superfamily. Proc Natl Acad Sci (United States) 93(2):878-883, 1996
Wall, N.A., Hogan, B.L.M. Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during bronchial arch development in the chick. Mech Dev 53(3):383-392, 1995
Ishidou, Y., Kitajima, I., Obama, H., Maruyama, I., Murata, F., Imamura, T., Yamada, N., ten Dijke, P., Miyazono, K., Sakou, T. Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation. J Bone Min Res 10(11):1651-1659, 1995
Luo, G., Hofmann, C., Bronckers, A.L.J., Sohocki, M., Bradley, A., Karsenty, G. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev 9(22):2808-2820, 1995
Dudley, A.T., Lyons, K.M., Robertson, E.J. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 9(22):2795-2807, 1995
Rosenzweig, B.L., Imamura, T., Okadome, T., Cox, G.N., Yamashita, H., ten Dijke, P., Heldin, C.H., Miyazono, K. Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc Natl Acad Sci (United States) 92(17):7632-7636, 1995
Marker, P.C., King, J.A., Copeland, N.G., Jenkins, N.A., Kingsley, D.M. Chromosomal localization, embryonic expression, and imprinting tests for BMP-7 on distal mouse chromosome 2. Genomics 28(3):576-580, 1995
Yamashita, H., ten Dijke, P., Huylebroeck, D., Sampath, T.K., Andries, M., Smith, J.C., Heldin, C.H., Miyazono, K. Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J Cell Bio (United States) 130(1):217-226, 1995
Liu, F., Ventura, F., Doody, J., Massague, J. Human type II receptor for bone morphogenic proteins (BMPs) extension of the two-kinase receptor model to the BMPs. Mol Cell Biol 15(7):3479-3486, 1995
Dewulf, N., Verschueren, K., Lonnoy, O., Moren, A., Grimsby, S., van de Spiegle, K., Miyazono, K., Huylebroeck, D., ten Dijke, P. Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis. Endo (United States) 136(6):2652-2663, 1995
Lyons, K.M., Hogan, B.L., Robertson, E.J. Colocalization of BMP-7 and BMP-2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development. Mech Dev (Ireland) 50(1):71-83, 1995
Helder, M.N., Ozkaynak, E., Sampath, K.T., Luyten, F.P., Latin, V., Oppermann, H., Vukicevic, S. Expression pattern of osteogenic protein-1 (bone morphogenetic protein-7) in human and mouse development. J Histoch Cytoch 45(10):1035-1044, 1995
Vukicevic, S., Latin, V., Chen, P., Batorsky, R., Reddi, A.H., Sampath, T.K. Localization of Osteogenic protein-1 (Bone Morphogenetic Protein-7) during Human Embryonic Development: High Affinity Binding to Basement Membranes. Biochem BioPhys Res Comm 198(2):693-700, 1994
Houston, B., Thorp, B.H., Burt, D.W. Molecular cloning and expression of bone morphogenetic protein-7 in the chick epiphyseal growth plate. J Mol Endo 13(3):289-301, 1994
Griffith, D.L., Oppermann, H., Rueger, D.C., Sampath, T.K., Tucker, R.F., Carlson, W.D. Crystallization and preliminary crystallographic data of recombinant human osteogenic protein-1. J Mol Biol (England) 244(5):657-658, 1994
Ten Dijke, P., Yamashita, H., Sampath, T.K., Reddi, A.H., Estevez, M., Riddle, D.L., Ichijo, H., Heldin, C.H., Miyazono, K. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem 269(25):16985-16988, 1994
Jones, W.K., Richmond, E.A., White, K., Sasak, H., Kusmik, W., Smart, J., Oppermann, H., Rueger, D.C., Tucker, R.F. Osteogenic Protein-1 (OP-1) Expression and Processing in Chinese Hamster Ovary Cells: Isolation of a Soluble Complex Containing the Mature and Pro-Domains of OP-1. Growth Fac 11:215-225, 1994
Sodek, J., Li, I.W.S., Li, H., Bellows, C.G., McCulloch, C.A.G., Tenenbaum, H.C., Ellen, R.P. The role of TGF-ß and BMP-7 in regenerating bone and soft tissues. Material Sci Engin C2:19-26, 1994
Sampath, T.K., Rashka, K.E., Doctor, J.S., Tucker, R.F., Hoffman, F.M. Drosophilia transforming growth factor B superfamily proteins induce endochondral bone formation in mammals. Proc Natl Acad Sci (United States) 90:6004-6008, 1993
Suzuki, A., Nishimatsu, S., Murakami, K., Ueno, N. Differential expression of Xenopus BMPs in early embryos and tissues. Zoolog Sci (Japan) 10(1):175-178, 1993
Nishimatsu, S., Suzuki, A., Shoda, A., Murakami, K., Ueno, N. Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos. Biochem Biophys Res Comm 186(3):1487-1495, 1992
Hahn, G.V., Cohen, R.B., Wozney, J.M., Levitz, C.L., Shore, E.M., Zasloff, A., Kaplan, S. A bone morphogenic protein subfamily: chromosome localization of human genes for BMP-5, BMP-6, and BMP-7. Genomics 14(3):759-762, 1992
Ozkaynak, E., Schnegelsberg, P.N., Jin, D.F., Clifford, G.M., Warren, F.D., Drier, E.A., Oppermann, H. Osteogenic protein-2 a new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. J Biol Chem 267(35):220-227, 1992
Sampath, T.K., Maliakal, J.C., Hauschka, P.V., Jones, W.K., Sasak, H., Tucker R.F., White, K.H., Coughlin, J.E., Tucker, M.M., Pang, R., Corbett, C., Ozkaynak, E., Oppermann, H., Rueger, D.C. Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J Biol Chem 267(28):20352-20362, 1992
Celeste, A.J., Ainnazzi, J.A., Taylor, R.C., Hewick, R.M., Rosen, V., Wang, E.A., Wozney, J.M. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci (United States) 87(24):9843-9847, 1990
Sampath, T.K., Coughlin, J.E., Whetstone, R.M., Banach, D., Corbett, C., Ridge R.J., Ozkaynak, E., Oppermann, H., Rueger, D.C. Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily. J Biol Chem 265(22):13198-13205, 1990
Ozkaynak, E., Rueger, D.C., Drier, E.A., Corbett, C., Ridge, R.J., Sampath, T.K., Oppermann, H. OP-1 cDNA encodes an osteogenic protein in the TGF-beta family. EMBO J (England) 9(7):2085-2093, 1990