Bone and Cartilage In Vitro Culture Studies
Vinall, R.L., Reddi,H. The Effect of BMP on the Expression of Cytoskeletal Proteins and Its Potential Relevance. JBJS 83-A(Supp 1, Part 1):63-69, 2001
Yeh, L-C. C., Mikhailov, V., Lee, J.C. Regulation of Expression of Plasminogen Activator Inhibitor-1 in Cultured Rat Osteoblastic Cells by osteogenic Protein-1 (BMP-7). J Cellular Biochem Supplement 36:46-24, 2001
Gruber, R., Mayer, C., Bobacz, K., Krauth, M-T., Graninger, W., Luyten, F.P., Erlacher, L. Effects of Cartilage-Derived Morphogenetic Proteins and Osteogenic protein-1 on Osteochondrogenic Differentiation of Periosteum-Derived Cells. Endocrinology 142(5):2087-2094, 2001
Ramoshebi, L.N., Ripamonti, U. Osteogenic Protein-1, a Bone Morphogenetic Protein, Induces Angiogenesis in the Chick Chorioallantoic Membrane and Synergizes With Basic Fibroblast Growth Factor and Transforming Growth Factor-ß1. Anatomical Record 259:97-107, 2000
Burger, A.H., Goei, S.W., Nelles, L., Ten, Dijke, P., Huylebroeck, D., Bornckers, A.L.J.J. Correlation between ALK-6(BMPR_IB) Distribution and Responsiveness to Osteogenic Protein-1 (BMP-7 in Embryonic Mouse Bone Rudiments. Growth Factors 17:177-192, 2000
Anderson, H.C., Hodges, P.T., Aguilera, X.M., Missana, L., Moylan, P.E. Bone Morphogenetic Protein (BMP) Localization in Developing Human and Rat Growth Plate, Metaphysis, Epiphysis, and Articular Cartilage. J Histochem Cytochem 48(11):1493-1502, 2000
Gruber, R., Mayer, C., Schulz, W., Ganinger, W., Peterlik, M., Watzek, G., Luyten, F.P., Erlacher, L. Stimulatory Effects of Cartilage-Derived Morphogenetic Proteins 1 and 2 on Osteogenic Differentiation of Bone Marrow Stromal Cells. CYTOKINE 12(11): 1630-1638, 2000
Yeh, L-C., Lee, J.C. Identification of an Osteogenic Protein-1 (Bone Morphogenetic Protein-7)-Responsive Element in the Promoter of the Rat Insulin-Like Growth Factor-Binding Protein-5 Gene. Endocrinology 141(9):3278-3286, 2000
Yeh, L.C.C., Unda, R., Lee, J.C. Osteogenic Protein-1 Differentially Regulates the mRNA Expression of Bone Morphogenetic Proteins and Their Receptors in Primary Cultures of Osteoblasts. J Cellular Physio 185:87-97, 2000
Chubinskaya, S., Merrihew, C., Cs-Szabo, G., Mollenhauer, J., McCartney, J., Rueger, D., Kuettner, K. Human Articular Chondrocytes Express Osteogenic Protein-1. J Histochemistry Cytochemistry 48(2):239-250, 2000
Yeh, L.C., Lee, J.C. Osteogenic protein-1 increases gene expression of vascular endothelial growth factor in primary cultures of fetal rat calvaria cells. Molecular Cellular Endocrinology 153:113-124, 1999
Koepp, H.E., Sampath, K.T., Kuettner, K. E., Homandberg, G.A. Osteogenic protein-1 (OP-1) blocks cartilage damage caused by fibronectin fragments and promotes repair by enhancing proteoglycan synthesis. Inflamm Res 47:1-6, 1999
Higashinakagawa, M. Biological effects of basic fibroblast growth factor (bFGF) and osteogenic protein-1 (OP-1/BMP-7) on bone marrow cells and development of cell-hybrid artificial bone. Kokubyo Gakkai Zasshi 66 (1):118-30, 1999
Enomoto-Iwamoto, M., Iwamoto, M., Mukudai, Y., Kawakami, Y., Nohno, T., Higuchi, Y., Takemoto, S., Ohuchi, H., Noji, S., Kurisu, K. Bone Morphogenetic Protein Signaling Is Required for Maintenance of Differentiated Phenotype, control of Proliferation ,and Hypertrophy in Chondrocytes. J Cell Biology 140(2):406-418, 1998
Mason, J. M., Grande, D. A., Barcia, M., Grant, R., Pergolizzi, R. G., Breitbart, A. S. Expression of human bone morphogenic protein 7 in primary rabbit periosteal cells: potential utility in gene therapy for osteochondral repair. Gene Ther 5(8):1098-1104, 1998
Yeh, L-C. C., Betchel, K.P., Lee, J.C. Inhibition of BMP receptor synthesis by antisense oligonucleotides attenuates OP-1 action in primary cultures of fetal rat calvaria cells. J Bone Mineral Res 13(12):1870-1879, 1998
Volk, S.W., Luvalle, P., Leask, T., Leboy, P.S. A BMP responsive transcriptional region in the chicken type X collagen gene. J Bone Miner Res 13(10):1521-1529, 1998
Klein-Nulend, J., Semeins, C.M., Mulder, J.W., Winters, H.A.H., Goei, S.W., Ooms, M.E., Burger, E.H. Stimulation of cartilage differentiation by osteogenic protein-1 in cultures of human perichondrium. J Tissue Eng 4(3):305-313, 1998
Grimsrud, C.D., Rosier, R.N., Puzas, J.E., Reynolds, P.R., Reynolds, S.D., Hicks, D.G., O'Keefe, R.J. Bone morphogenetic protein-7 in growth-plate chondrocytes: Regulation by retinoic acid is dependent on the stage of chondrocyte mutation. J Ortho Res (United States) 16(2):247-255, 1998
Terkeltaub, R.A., Johnson, K., Rohnow, D., Goomer, R., Burton, D., Deftos, L.J. Bone morphogenetic proteins and bFGF exert opposing regulatory effects on PTHrP expression and inorganic pyrophosphate elaboration in immortalized murine endochondral hypertrophic chondrocytes (MCT cells). J Bone Miner Res (United States) 13(6):931-941, 1998
Zohar, R., McCulloch, C.A.G., Sampath K., Sodek, J. Flow cytometric analysis of recombinant human osteogenic protein-1 (BMP-7) responsive subpopulations from fetal rat calvaria based on intracellular osteopontin content Matrix. Biol (Germany) 16(6):295-306, 1998
Yeh, L.C.C., Adamo, M.L., Duan, C., Lee, J.C. Osteogenic protein-1 regulates insulin-like growth factor-I (IGF-I), IGF-II, and IGF-binding protein-5 (IGFBP-5) gene expression in fetal rat calvaria cells by different mechanisms. J of Cell Phys 175(1):78-88, 1998
Erlacher, L., McCartney, J., Piek, E., Dijke, P.T., Yanagishita, M., Oppermann, H., Luyten, F.P. Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis. J Bone Min Res (United States) 13(3):383-392, 1998
Klein-Nulend, J., Louwerse, R.T., Heyligers, I.C., Wuisman, P.I., Semeins, C.M., Goei, S.W., Burger, E.H. Osteogenic protein (OP-1, BMP-7) stimulates cartilage differentiation of human and goat perichondrium tissue in vitro. J Biomed Mater Res 40(4):614-620, 1998
Erlacher, L., Ng, C.K., Ullrich, R., Krieger, S., Luyten, F.P. Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro. Arth Rheum 41(2):263-273, 1998
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A.L., Karsenty, G. Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation. Cell 89:747-754, 1997
Haaijman, A., D'Souza, R.N., Bronckers, A.L., Goei, S.W., Burger E.H. OP-1 (BMP-7) affects mRNA expression of type I, II, X collagen, and matrix Gla protein in ossifying long bones in vitro. J. Bone Min Res (United States) 12(11):1815-1823, 1997
Huch, K., Wilbrink, B., Flechtenmacher, J., Koepp, H.E., Aydelotte, M.B., Sampath, T.K., Kuettner, K.E., Mollenhauer, J., Thonar, E.J. Effects of recombinant human osteogenic protein 1 on the production of proteoglycan, prostaglandin E2, and interleukin-1 receptor and antagonist by human articular chondrocytes cultured in the presence of interleukin-1. Arth Rheum (United States) 40(12):2157-2161, 1997
Wu, L.N.Y., Ishikawa, Y., Genge, B.R., Sampath, T.K., Wuthier, R.E. Effect of osteogenic protein-1 on the development and mineralization primary cultures of avian growth plate chondrocytes: Modulation by retinoic acid. J Cell Bioch 67(4):498-513, 1997
Kitten, A., Harvey, S., Criscimagna, N., Asher, M., Lee, J.C., Olson, M.S. Osteogenic protein-1 downregulates endothelin A receptors in primary rat osteoblasts. Am. J. Physiol 272(6):E967-E975, 1997
Macias, D., Ganan, Y., Sampath, T.K., Piedra, M.E., Ros, M.A., Hurle, J.M. Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development. Development (Cambridge) 124(6):1109-1117, 1997
Yeh, L.C.C., Adamo, M.L., Olson, M.S., Lee, J.C. Osteogenic protein-1 and insulin-like growth factor I synergistically stimulate rat osteoblastic cell differentiation and proliferation. Endocrinology 138(10):4181-4190, 1997
Hayden, J.M., Strong, D.D., Baylink, D.J., Powell, D.R., Sampath, T.K., Mohan, S. Osteogenic protein-1 stimulates production of insulin-like growth factor binding protein-3 nuclear transcripts in human osteosarcoma cells. Endocrinology 138(10):4240-4247, 1997
Srinivasan, N., Baylink, D.J., Sampath, K., Mohan, S. Effects of inhibitors of signal transduction pathways on transforming growth factor beta 1 and osteogenic protein-1 induced insulin-like growth factor binding protein-3 expression in human bone cells. J of Cell Phys 173(1):28-35, 1997
Lietman, S.A., Yanagishita, M., Sampath, T.K., Reddi, A.H. Stimulation of proteoglycan synthesis in explants of porcine articular cartilage by recombinant osteogenic protein-1 (bone morphogenetic protein-7). J Bone Joint Surg Am (United States) 79(8):1132-1137, 1997
Honda, Y., Knutsen, R., Strong, D.D., Sampath, T.K., Baylink, D.J., Mohan, S. Osteogenic protein-1 stimulates mRNA levels of BMP-6 and decreases mRNA levels of BMP-2 and -4 in human osteosarcoma cells. Calcified Tiss Intnl 60(3):297-301, 1997
Renier, M.L., Kohn, D.H. Development and characterization of a biodegradable polyphosphate. J Biomed Mat Res 34(1):95-104, 1997
Cheifetz, S., Li, I.W.S., McCulloch, C.A.G., Sampath, K., Sodek, J. Influence of osteogenic protein-1 (OP-1, BMP-7) and transforming growth factor- 1 on bone formation in vitro. Connect Tiss Res 35(1-4):71-78, 1996
Yeh, L-C.C., Adamo, M.L., Kitten, A.M., Olson, M.S., Lee, J.C. Osteogenic protein-1 mediated insulin-like growth factor gene expression in primary cultures of rat osteoblastic cells. Endocrinology (United States) 137(5):1921-1931, 1996
Mayer, H., Scutt, A.M., Ankenbauer, T. Subtle differences in the mitogenic effects of recombinant human bone morphogenetic protein-2 to protein-7 on DNA-synthesis on primary bone-forming cells and identification of BMP-2/4 receptor. Calcified Tiss Intnl 58(4):49-255, 1996
Dee, K.C., Rueger, D.C., Andersen, T.T., Bizios, R. Conditions which promote mineralization at the bone-implant interface - a model in-vitro study. Biomaterials 17(2):209-215, 1996
Asahina, I., Sampath, T.K., Hauschka P.V. Human osteogenic protein-1 induces chondroblastic, osteoblastic, and/or adipocytic differentiation of clonal murine target cells. Exp Cell Res 222(1):38-47, 1996
Kitten, A.M., Lee, J.C., Olson, M.S. Osteogenic protein-1 enhances phenotypic expression in ROS 17/2.8 cells. Am J Physiol 269(5 Pt 1):E918-E926, 1995
Wall, N.A., Hogan, B.L. Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during bronchial arch development in the chick. Mech Dev (Ireland) 53(3):383-392, 1995
Mohan, S., Libanati, C., Dony, C., Lang, K., Srinivasan, N., Baylink, D.J. Development, validation, and application of radioimmunoassay for insulin-like growth factor binding protein-5 in human serum and other biological fluids. J Clin Endo Metab (United States) 80(9):2638-2645, 1995
Kanzaki ,S., Baxter, R.C., Knutsen, R., Baylink ,D.J., Mohan, S. Evidence that human bone cells in culture secrete insulin-like growth factor (IGF)-II and IGF binding protein-3 but not acid-labile subunit both under basal and regulated conditions. J Bone Min Res (United States) 10(6):854-858, 1995
Sodek, J., Chen, J., Nagata, T., Kasugai, S., Todescan, R. Jr., Li, I.W., Kim, R.H. Regulation of osteopontin expression in osteoblasts. Ann NY Acad Sci 760:223-241, 1995
Hentunen, T.A., Lakkakorpi, P.T., Tuukkanen, J., Lehenkari, P.P., Sampath, T.K., Vaananen, H.K. Effects of recombinant human osteogenic protein-1 on the differentiation of osteoclast-like cells and bone resorption. Biochem Biophys Res Commun (United States) 209(2):433-443, 1995
Knutsen, R., Honda, Y., Strong, D.D., Sampath, T.K., Baylink, D.J., Mohan, S. Regulation of insulin-like growth factor system components by osteogenic protein-1 in human bone cells. Endo (United States) 136(3):857-865, Mar 1995
Chen, P., Vukicevic, S., Sampath, T.K., Luyten, F.P. Osteogenic protein-1 promotes growth and maturation of chick sternal chondrocytes in serum-free cultures. J Cell Sci (England) 108(1):105-114, 1995
Postlethwaite, A.E., Raghow, R., Stricklin, G., Ballou, L., Sampath, T.K. Osteogenic protein-1, a bone morphogenic protein member of the TGF-beta superfamily, shares chemotactic but not fibrogenic properties with TGF-beta. J Cell Physiol (United States) 161(3):562-570, 1994
Dieudonne, S.C., Semeins, C.M., Goei, S.W., Vukicevic, S., Nulend, J.K., Sampath, T.K., Helder, M., Burger, E.H. Opposite effects of osteogenic protein and transforming growth factor beta on chondrogenesis in cultured long bone rudiments. J Bone Min Res 9(6):771-780, 1994
Maple, R., Baylink, D.J., Sampath, T.K., Mohan, S. Evidence that human bone cells in culture contain binding sites for osteogenic protein-1. Biochem Biophys Res Comm 201(2):1140-1147, 1994
Maliakal, J.C., Asahina, I., Hauschka, P.V., Sampath, T.K. Osteogenic protein-1 (BMP-7) inhibits cell proliferation and stimulates the expression of markers characteristic of osteoblast phenotype in rat osteosarcoma (17/2.8) cells. Growth Fac (Switzerland) 11(3):227-234, 1994
Chen, P., Vukicevic, S., Sampath, T.K., Luyten, F.P. Bovine articular chondrocytes do not undergo hypertrophy when cultured in the presence of serum and osteogenic protein-1. Biochem Biophys Res Comm 197(3):1253-1259, 1993
Asahina, I., Sampath, T.K., Nishimura, I., Hauschka, P.V. Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria. J Cell Biol 123(4):921-933, 1993
Knutsen, R., Wergedal, J.E., Sampath, T.K., Baylink, D.J., Mohan, S. Osteogenic protein-1 stimulates proliferation and differentiation of human bone cells in vitro. Biochem Biophys Res Comm, 194(3):1352-1358, 1993