The active ingredient in OP-1 Implant is recombinant human bone morphogenetic protein-7 (rhBMP-7), or Osteogenic Protein 1, formulated with a purified Type I collagen carrier. Once implanted, OP-1 stimulates natural bone healing by actively recruiting stem cells from surrounding tissue and blood supply, initiating the bone formation cascade. Through many years of research, the mechanism of action by which this molecule works inside the body has been studied extensively.
OP-1 Implant is approved by the FDA under a Humanitarian Device Exemption (HDE) and is indicated for use as an alternative to autograft in recalcitrant long bone nonunions where use of autograft is unfeasible and alternative treatments have failed. OP-1 Implant is approved in 28 additional countries, including Australia, Canada, and the European Union.
OP-1 Implant is a combination of 3.5 mg of recombinant human BMP-7 (rhBMP-7) and 1 g of purified Type I bovine collagen, which is used as a carrier. The product is reconstituted with 2-3 cc of saline to form a paste which is then implanted at the nonunion site.
See the package insert for OP-1 Implant for the complete list of indications, warnings, precautions, adverse events, clinical results and other important medical information.
For a list of Frequently Asked Questions regarding OP-1 Implant, click here.
Features & Benefits
- 3.5 mg of recombinant human OP-1 (BMP-7), a recombinant version of a natural growth factor
- Proven osteoinductivity
- Compatible with current surgical techniques
- Contains collagen matrix, an optimal carrier for BMP-7
- Compression-resistant carrier for improved containment of BMP-7
- Easy to use with reduced set up time