Constructed to wick4

Tritanium In-Growth Technology with porcine bone marrow aspirate*

This in-vitro study demonstrated that a cube built with Tritanium material was able to wick fluid into the porous structure under specified conditions.4

It also absorbed and held fluid inside the porous structure.4

More BMA absorption than allograft and PEEK5

The Tritanium C Cage demonstrated it absorbed 3 times more bone marrow aspirate (BMA) than allograft and 4 times more BMA than PEEK, in an in vitro study.5

allograft

*This experiment was performed using heparinized porcine bone marrow aspirate. No correlation to human clinical outcomes has been demonstrated or established.

Designed to create a favorable environment for cells2,3

A coupon built with Tritanium In-Growth Technology demonstrated that osteoblasts (bone cells) infiltrated, attached to and proliferated on the porosity of the Tritanium technology2. The unique porous structure is designed to create a favorable environment for cell attachment and proliferation2,3.

environmentb
environmenta
environmentc
environmentd
environmente
  • - Osteoblasts

  • - Tritanium In-Growth Technology

Normal human osteoblast cells were used for in-vitro cell studies. No correlation to human clinical outcomes has been demonstrated or established.

*Image depicts a sample built with Tritanium Technology used for in vitro cell studies. The sample was designed to mimic a generic interbody cage with an open graft window. This is not an implantable device.

Designed for in-growth

Tritanium technology has been designed for bone in-growth, and biological fixation1.

  • Cancellous bone characteristics3

    Average pore diameter of cancellous bone = 1 mm

    Average porosity of cancellous bone = 50–90%

  • Tritanium material characteristics6

    Randomized pore sizing designed to mimic cancellous bone - Pore size range: 100-700 μm - Mean pore size range: 400-500 μm

    Interconnected pore structure from endplate to endplate

    Mean porosity range: 55-65%

*In spinal implants

Pre-clinical research

week8 week16
peek-cage-img peek-cage-img
ti-coated-img ti-coated-img
tritanium-pl-img tritanium-pl-img

Sagittal view images. Correlation to human outcomes has not been demonstrated or established.

week8-big
tritanium-img tritanium-img

Sagittal view image. Correlation to human outcomes has not been demonstrated or established.

Material characteristics forTritanium In-Growth Technology1

  • Strong, stiff and biocompatible material9

    Made from titanium alloy

  • Highly porous material3,10,11

    Porosity > 46%

    Average pore diameter > 300μm

    Mean porosity range: 55-65%

    Pore diameter range: 100-700μm

    Mean pore size range: 400-500μm

  • Interconnected porosity12

    Porosity on superior and inferior surfaces and within internal walls

  • Roughened surface9,13

    Coefficient of friction = .92

  • Porous architecture reflective of bone composition3

    Tritanium material consists of random interconnected architecture with rugged,irregular pore sizes and shapes that are designed to mimic cancellous bone

  • Manufacturing process capable of reproducible randomization

    Utilizes proprietary additive manufacturing technique to produce completely randomized yet reproducible porous structure

  • Ability to wick and retain fluid14

    Tritanium material may be able to wick or retain fluid in comparison to traditional titanium material4. Tritanium material demonstrated the ability to wick fluid into the porous structure under specified conditions during an experiment.It also absorbed and held fluid inside the porous structure4

    The Tritanium C Cage absorbed 3 times more bone marrow aspirate (BMA) than allograft and 4 times more BMA than PEEK in an in-vitro study5

  • Realistic environment for cell growth15

    Coupon built with Tritanium material demonstrated that osteoblasts (cells) infiltrated, attached to and proliferated on the porosity of the Tritanium technology 2. The unique porous structure is designed to create a favorable environment for cell attachment and proliferation2,3

Note: Tritanium is a novel highly porous titanium material designed for bone in-growth and biological fixation. These claims are exclusively associated with Tritanium Technology, used to build the Tritanium PL and C Cages.

News & events

Keep up with Stryker news to stay informed and up to date with the latest in medical technology.

Recent news

  • news-aaos AAOS 2017

    New Tritanium PL Cage sizes debut at AAOS...

    More

  • news-animal Animal Study

    Pre-Clinical study presented at NASS...


    More

  • news-vr NASS 2016

    Experience virtual reality at NASS 2016...


    More

  • news-4 Tritanium posterior lumbar cage debuts

    Stryker's Spine division will introduce the Tritanium Posterior Lumbar (PL) Cage... More

  • news-3 Stryker receives FDA clearance for Tritanium

    Advanced 3D additive manufacturing technology used to create proprietary tritanium... More

Upcoming events


For information or images requests, contact:

Jodie Morrow

Manager, Communications
Stryker

Barbara Sullivan

President
Sullivan & Associates

Featuring Tritanium In-Growth Technology1Built to fuseTM

Request more information
  1. PROJ43909 | Tritanium technology claim support memo
  2. RD0000053710 | Tritanium cell infiltration and attachment experiment
  3. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials. 2005 Sep;26(27):5474-91
  4. RD0000050927 | Tritanium material capillary evaluation
  5. RD0000053906 | Tritanium cervical competitive wicking comparison
  6. DHF0000042351 and DHF0000053171
  7. Pre-clinical study final report, SRL 15-02 / Stryker 02-15
  8. RD0000054287 Tritanium C sheep study 8-week interim report. These data are reflected in an interim report that is subject to change until release of the final study report
  9. Oldani C, Dominguez A. Titanium as a Biomaterial for Implants. Recent Advances in Arthroplasty. Dr. Samo Fokter (Ed.). ISBN: 978-953-307-990-5. 2012. InTech
  10. Kujala, S. et al (2003): “Effect of porosity on the osteointegration and bone ingrowth of a weight-bearing nickel–titanium bone graft substitute”, Biomaterials, 24(25), November 2003, Pages 4691-4697
  1. Bobyn JD, Pilliar RM, Cameron HU, Weatherly GC. (1980) The optimum pore size for the fixation of porous-surfaced metal implants by the ingrowth of bone. Clinical Orthopaedics and Related Research, 150, 263-270
  2. Simon JL, Roy TD, Parsons JR, Rekow ED, Thompson VP, Kemnitzer J, et al. Engineeredcellular response to scaffold architecture in a rabbit trephine defect. J Biomed Mater Res A 2003;66(2):275–82
  3. Deligianni, D.D.; Katsala, N.; Ladas, S.; Sotiropoulou, D.; Amedee, J.; & Missirlis, Y.F. (2001) Effect of surface roughness of the titanium alloy Ti-6Al-4V on human bone marrow cell response and on protein adsorption. Biomaterials, 22, 1241-1251
  4. Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness
  5. M. J. Cooke; Enhanced cell attachment using a novel cell culture surface presenting functional domains from extracellular matrix proteins. Cytotechnology. 2008 Feb; 56(2): 71–79

Refer to the Tritanium C and Tritanium PL surgical techniques and instructions for use for complete product information
This website is intended for physicians only. It is not intended for patients. If you are a patient, you should not rely on the information on this website and should speak to your doctor about whether spinal fusion surgery is right for you.

A surgeon must always rely on his or her own professional clinical judgment when deciding whether to use a particular product when treating a particular patient. Stryker does not dispense medical advice and recommends that surgeons be trained in the use of any particular product before using it in surgery.

The information presented is intended to demonstrate the breadth of Stryker product offerings. A surgeon must always refer to the package insert, product label and/or instructions for use before using any Stryker product. Products may not be available in all markets because product availability is subject to the regulatory and/or medical practices in individual markets. Please contact your Stryker representative if you have questions about the availability of Stryker products in your area.

Stryker Corporation or its divisions or other corporate affiliated entities own, use or have applied for the following trademarks or service marks: AMagine, Built to fuse,Stryker, Tritanium. All other trademarks are trademarks of their respective owners or holders.

TRITA-WB-2_Rev-1_15842

Copyright © 2017 Stryker

Developed to minimize subsidence1



chart

Developed to minimize subsidence1

The Tritanium PL Cage demonstrated better resistance to subsidence than other commercially available posterior lumbar interbody cages constructed out of different materials, including those with a larger footprint.1

  • Porous Tritanium has an elastic modulus that falls between cancellous and cortical bone1

  • Large central graft and lateral windows help to reducethe overall stiffness of the cage and allow room for bone graft to be packed inside the cage1

  • Teeth are designed to increase the surface area of the device in contact with bone in order to help normalize load transmission and minimize subsidence1

Created to allow imaging

With large lateral windows, Tritanium PL allows visualization on CT and X-ray.

  • xray
  • ct

Images taken from a cadaveric study 2

Engineered for stability3,4

engchart

Engineered for stability3,4

The precisely angled teeth of the Tritanium PL Cage are designed to allow bidirectional stability, with an expulsion force that was shown to be 22% greater than the insertion force.3

  • Teeth with a smooth leading edge aid movement across the vertebral endplates

  • High coefficient of friction for initial stability4

Tritanium PL Cage technical data9

  • Titanium alloy
  • 55-65%
  • 400-500 μm
  • 100-700 μm
  • Full, endplate to endplate
  • Lengths23 and 28 and 32mm
  • Widths9 and 11 mm
  • Lordosis0, 6 and 12°
  • Heights7–14 mm
  1. Subsidence memo PROJ42624.
  2. Tritanium PL Cage cadaveric image folder / Stryker document #0000047030.
  3. Insertion/expulsion memo PROJ42623.
  4. Coefficient of friction memo PROJ44960.

Refer to the Tritanium C and Tritanium PL surgical techniques and instructions for use for complete product information

This website is intended for physicians only. It is not intended for patients. If you are a patient, you should not rely on the information on this website and should speak to your doctor about whether spinal fusion surgery is right for you.

A surgeon must always rely on his or her own professional clinical judgment when deciding whether to use a particular product when treating a particular patient. Stryker does not dispense medical advice and recommends that surgeons be trained in the use of any particular product before using it in surgery.

The information presented is intended to demonstrate the breadth of Stryker product offerings. A surgeon must always refer to the package insert, product label and/or instructions for use before using any Stryker product. Products may not be available in all markets because product availability is subject to the regulatory and/or medical practices in individual markets. Please contact your Stryker representative if you have questions about the availability of Stryker products in your area.

Stryker Corporation or its divisions or other corporate affiliated entities own, use or have applied for the following trademarks or service marks: AMagine, Built to fuse,Stryker, Tritanium. All other trademarks are trademarks of their respective owners or holders.\

TRITA-WB-2_Rev-1_15842

Copyright © 2017 Stryker

The AMagine Institute is the world’s largest additive manufacturing facilityfor orthopaedic implants.

AMagine is Stryker’s proprietary approach to implant creation using additive manufacturing (AM). Additive manufacturing allows us to push beyond conventional manufacturing techniques to address design complexity and achieve previously unmanufacturable geometries, but also to deliver the performance, reproducibility and quality you expect from our products.

Stryker’s investment in additive manufacturing began in 2001 and, since then, Stryker has collaborated with leading universities in Ireland and the UK to industrialize 3D printing for the healthcare industry.

The AMagine Institute, Stryker’s new global technology development center/hub located in Cork, Ireland, is the world’s largest additive manufacturing facility for orthopaedic implants. Among the most advanced AM facilities of its kind, it is where bright ideas are transformed into exciting new implants, for use in spinal surgery.

AMagine, which incorporates hundreds of quality checks per batch, enables us to design and build the Tritanium PL and C Cages with pinpoint precision, optimizing every property of the device, from pore size and porosity to shape and surgical features.1

Originally launched for hip and knee implants, Stryker’s Tritanium technology has been proven in over 10 years of clinical experience with more than 300,000 orthopedic devices implanted.1

  1. Data on file, Stryker’s Spine Division

Refer to the Tritanium C and Tritanium PL surgical techniques and instructions for use for complete product information

This website is intended for physicians only. It is not intended for patients. If you are a patient, you should not rely on the information on this website and should speak to your doctor about whether spinal fusion surgery is right for you. A surgeon must always rely on his or her own professional clinical judgment when deciding whether to use a particular product when treating a particular patient. Stryker does not dispense medical advice and recommends that surgeons be trained in the use of any particular product before using it in surgery.

The information presented is intended to demonstrate the breadth of Stryker product offerings. A surgeon must always refer to the package insert, product label and/or instructions for use before using any Stryker product. Products may not be available in all markets because product availability is subject to the regulatory and/or medical practices in individual markets. Please contact your Stryker representative if you have questions about the availability of Stryker products in your area.

Stryker Corporation or its divisions or other corporate affiliated entities own, use or have applied for the following trademarks or service marks: AMagine, Built to fuse,Stryker, Tritanium. All other trademarks are trademarks of their respective owners or holders.

Built with laser precision,layer by layer1

empowered-by-expertise empowered-by-expertise

Developed to minimize subsidence2


The Tritanium C Cage demonstrated better resistance to subsidence than other commercially available cervical interbody cages constructed out of different materials.2

  • Large central graft and lateral windows help to reduce the overall stiffness of the cage and allow room for bone graft to be packed inside the cage2

  • Porous Tritanium has an elastic modulus that falls between cancellous and cortical bone3

  • Teeth are designed to increase the surface area of the device in contact with bone in order to help normalize load transmission and minimize subsidence3

engchart

Created to allow imaging

Designed with lateral windows, the Tritanium C Cage allows visualization on CT and X-ray.

  • titenumct
  • tritaniumxray

Images taken from a cadaveric study 4

Shaped for stability5,6

shapchart

Shaped for stability5,6


The precisely angled teeth of the Tritanium C Cage are designed to allow bidirectional stability, with an expulsion force that was shown to be 9% greater than the insertion force.5

  • Tritanium C cervical cages have a high coefficiency of friction for initial stability6

  • Individually sterile-packed, and available in broad range of footprints, heights and lordotic angles, the Tritanium C Cage is designed to address varying patient anatomy

    • Slopes on both the superior and inferior aspects of the cage allow hyper-lordotic options to optimize sagittal balance

    • Indicated for use in one level or two contiguous level cervical interbody fusions

Tritanium C Cage technical data

  • Titanium alloy
  • 55-65%
  • 400-500 μm
  • 100-700 μm
  • Full, endplate to endplate
  • Footprints12x14mm, 14x17mm
  • Lordotic angles0, 6 and 10°
  • Heights5-9 mm
  1. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials. 2005 Sep;26(27):5474-91
  2. PROJ0000054457 | Tritanium C subsidence marketing memo
  3. PROJ42624 | Tritanium PL subsidence memo
  4. PROJ0000054459 | Tritanium C implant imaging marketing memo
  5. PROJ0000054458 | Tritanium C insertion and expulsion marketing memo
  6. PROJ44960 | Coefficient of friction memo.

Refer to the Tritanium C and Tritanium PL surgical techniques and instructions for use for complete product information

This website is intended for physicians only. It is not intended for patients. If you are a patient, you should not rely on the information on this website and should speak to your doctor about whether spinal fusion surgery is right for you. A surgeon must always rely on his or her own professional clinical judgment when deciding whether to use a particular product when treating a particular patient. Stryker does not dispense medical advice and recommends that surgeons be trained in the use of any particular product before using it in surgery.

The information presented is intended to demonstrate the breadth of Stryker product offerings. A surgeon must always refer to the package insert, product label and/or instructions for use before using any Stryker product. Products may not be available in all markets because product availability is subject to the regulatory and/or medical practices in individual markets. Please contact your Stryker representative if you have questions about the availability of Stryker products in your area.

Stryker Corporation or its divisions or other corporate affiliated entities own, use or have applied for the following trademarks or service marks: AMagine, Built to fuse,Stryker, Tritanium. All other trademarks are trademarks of their respective owners or holders.

TRITA-WB-2_Rev-1_15842

Copyright © 2017 Stryker